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急性心肌梗塞(AMI)甲皱微循环改变明显重于非梗塞冠心病人和健康人(P<0.01)。AMI 甲皱微循环改变以管襻周围及血液流态改变为重,与病情、梗塞面积、左室射血分数、ECG 急性期 ST 段抬高水平及血清磷酸肌酸激酶密切相关(r=0.9483、-0.9040、0.9083、0.9562,P均<0.01)。AMI 出现并发症,甲皱微循环改变加重,并发症越多,甲皱微循环改变越重。AMI 甲皱微循环检测、动态检测及有条件连续监测回放录像有益指导治疗、改善预后。尿激酶溶栓、肝素抗凝治疗可使微循环明显改善,疗效优于精制抗栓酶、低分子右旋糖酐等药物治疗(P<0.01和P<0.05)。AMI 甲皱微循环改变与梗塞部位无关。不稳定心绞痛甲皱微循环改变明显重于稳定性心绞痛(P<0.01),及时治疗改善不稳定性心绞痛患者的甲皱微循环可以减少 AMI 的发病率。
Acute myocardial infarction (AMI) nail fold microcirculation changes were significantly heavier in non-infarction patients with coronary heart disease and healthy people (P <0.01). The change of microcirculation in AMI was related to the change of blood flow around the tube and blood flow, which was closely related to the condition, infarction area, left ventricular ejection fraction, ST segment elevation in acute stage of ECG and serum creatine phosphokinase (r = 0.9483 , -0.9040,0.9083,0.9562, P <0.01). AMI complications, nail fold microcirculation changes aggravate, the more complications, nail fold microcirculation change more. AMI nail fold microcirculation detection, dynamic detection and conditional continuous monitoring playback video beneficial guiding therapy to improve the prognosis. Urokinase thrombolysis, heparin anticoagulation therapy can significantly improve microcirculation, curative effect is better than refined antithrombin enzyme, low molecular weight dextran and other drug treatment (P <0.01 and P <0.05). AMI nail fold microcirculation has nothing to do with the infarct site. Unstable angina nail fold microcirculation changes significantly more than the stability of angina (P <0.01), timely treatment of patients with unstable angina improve nail fold microcirculation can reduce the incidence of AMI.