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目的探讨重度羊水胎粪污染新生儿抗生素的合理使用。方法选取2010年9月至2013年9月在博白县妇幼保健院出生的新生儿资料308例,按随机数字表法将其分为对照组与观察组,各154例。观察组新生儿按新药标准用药,对照组新生儿按经验用药。比较两组新生儿的抗生素使用率、第1代头孢使用率、口服抗生素率及感染性疾病发生率。结果观察组新生儿的抗生素使用率、第1代头孢使用率、口服抗生素率均明显低于对照组,差异均有统计学意义(均P<0.05)。结论对于重度羊水胎粪污染的新生儿,可根据相关的药物指导意见,合理使用抗生素。
Objective To investigate the rational use of antibiotics in neonates with severe meconium-stained amniotic fluid. Methods 308 cases of newborns born in Mabey and MCH in Bobai County from September 2010 to September 2013 were selected and divided into control group and observation group by random number table method, each of 154 cases. Newborns in the observation group were treated with new drugs and neonates in the control group were treated according to experience. The antibiotic use rate, first-generation cephalosporin use rate, oral antibiotic rate and infectious disease incidence in two groups were compared. Results The neonatal antibiotic use rate, first-generation cephalosporin usage rate and oral antibiotic rate in the observation group were significantly lower than those in the control group (all P <0.05). Conclusion For severe neonatal meconium-stained amniotic fluid, according to the relevant drug guidance, the rational use of antibiotics.