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目的观察γ-氨基丁酸(γ-aminobutyric acid,GABA)对吗啡依赖大鼠中枢神经系统伏隔核(nucleus accumbens,NAc)痛兴奋神经元(pain-excited neurons,PEN)电活动的影响。方法脑室或NAc中注射GABA或荷包牡丹碱(bicuculline,Bic),电脉冲刺激右侧坐骨神经作为伤害性疼痛刺激,用玻璃微电极在细胞外记录中枢神经系统伏隔核痛兴奋神经元电活动的变化。结果脑室及NAc中注入GABA均能使吗啡依赖大鼠NAc中PEN潜伏期延长、痛诱发放电频率减少;GABAA受体拮抗剂Bic能够阻断GABA的上述效应。结论外源性GABA在中枢痛觉调制中起抑制作用,GABA及GABAA受体参与介导中枢伤害性信息的传递过程。
Objective To observe the effect of γ-aminobutyric acid (GABA) on the electrical activity of pain-excited neurons (PEN) in the nucleus accumbens (NAc) of the central nervous system in morphine-dependent rats. Methods GABA or bicuculline (Bic) was injected into the ventricles or NAc. The right sciatic nerve was stimulated by nocturnal stimulation as a nociceptive pain. The electrical activity of pain excitatory neurons in the nucleus accumbens of the central nervous system was recorded by glass microelectrodes Variety. Results GABA injection into the ventricles and NAc prolonged the latency of PEN in morphine-dependent NAc rats and decreased the frequency of pain-induced discharge. GABAA receptor antagonist Bic blocked the above effects of GABA. Conclusions Exogenous GABA plays an inhibitory role in central pain modulation. GABA and GABAA receptors are involved in mediating the transmission of central nociceptive information.