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Selye 于1959年的报导中,认为钾是一种对心肌有保护作用的离子,在损伤或梗塞的心肌纤维,因心肌细胞内失钾而降低了膜静息电位或极化。并指出心肌对心脏毒性物质的耐受性可因细胞内低钾和低镁而降低,若一旦离子恢复平衡,心肌对毒性物质的耐受性亦即恢复平衡。Sodi——Pallares 于1960年第一次报导应用葡萄糖——胰岛素——钾(GIK)治疗许多心血管疾病取得了疗效。之后,不少
Selye reported in 1959 that potassium is a cardiomyocyte-protective ion that reduces membrane resting potential or polarization in injured or infarcted myocardial fibers due to loss of potassium in cardiomyocytes. And pointed out that myocardial tolerance to cardiac toxic substances can be reduced due to intracellular hypokalemia and low magnesium, once the ions return to equilibrium, myocardial tolerance to toxic substances that is to restore balance. Sodi - Pallares first reported in 1960 the application of glucose - insulin - potassium (GIK) for the treatment of many cardiovascular diseases and achieved efficacy. After a lot of