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甲氧苄氨嘧啶(TMP)片的含量测定,中国药典1977年版采用非水法,即先用温热的氯仿提取,提取液蒸干,然后加冰醋酸溶解,再用高氯酸液滴定。此法操作烦琐,而且氯仿毒性较大,有碍健康,因此我们改进了药典方法,去掉了氯仿提取一步。由于片剂中的硬脂酸镁也消耗高氯酸,使直接滴定结果偏高,因此中国药典法用氯仿提取以排除干扰。据我们试验,如果不经提取,直接用冰醋酸溶解,高氯酸液滴定,结果偏高约1.9%(按我厂处方硬脂酸镁的量为主药2%试验),见表1。
Trimethoprim (TMP) tablets content determination, Chinese Pharmacopoeia 1977 edition using non-aqueous method, that is, first with warm chloroform extraction, the extract was evaporated to dryness, then add glacial acetic acid dissolved, and then perchloric acid titration. This method is cumbersome to operate and has high toxicity to chloroform, which is detrimental to health. Therefore, we improved the pharmacopoeial method by removing one step of chloroform extraction. Since the magnesium stearate in the tablets also consumes perchloric acid, the direct titration result is so high that the Chinese Pharmacopoeia method is extracted by chloroform to eliminate the interference. According to our test, without extraction, directly dissolved with glacial acetic acid, perchloric acid titration, the result is high about 1.9% (according to my factory prescription magnesium stearate 2% of the main drug test), shown in Table 1.