过去15年内,肝移植已成为挽救终末期肝病患者的治疗方法,但有关儿童患者的初步经验不多。Johns Hopkins医院在过去4.5年内曾为13例1岁以下婴儿施行了17次肝移植。术中给甲基去氢泼尼松一次剂量10mg/kg,随后10天内渐减至1mg·kg~(-1)·d~(-1),其后1个月内,逐步减量至0.3mg·kg~(-1)·d~(-1),后隔天用药3个月, In the past 15 years, liver transplantation has become a cure for salvage of patients with end-stage liver disease, but preliminary experience with children is poor. Johns Hopkins Hospital has performed 17 liver transplants in 13 infants under the age of 1 in the past 4.5 years. Intraoperative methyltrahydroprusside a dose of 10mg / kg, then reduced to 10mg · kg -1 (-1) · d -1 within 10 days, then within 1 month, gradually reduced to 0.3 mg · kg ~ (-1) · d ~ (-1), the next day medication for 3 months,