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Norplant~R是一种仅含孕激素(左旋18甲简称LNg)的长效埋植避孕剂,它因不含雌激素而无雌激素引起的副作用,且具有高效、低剂量缓慢释放的特点,保证较长时间血药浓度稳定,可避免甾体口服给药引起的血药浓度波动。妇女长期应用Norplant~R无血LNg水平的蓄积作用,表明其代谢廓清率大于释放率。本研究目的是测定取出Norplant~R后排卵恢复所需要的时间。研究包括10名妇女,年龄31.9±5.6岁(23～39),产次4±2.3次(2～7),体重68.0±16kg(57～107),皮下埋植Norplant~R时间为26.2±7.3个月(11～36),每例埋植6囊,每囊长3cm,含LNg34±2mg。10例中因月经不规则取出5例(月经过多3例,突破性出血1例,闭经1例),因持续头痛取出2例,其余3例因非医源性原因(2例计划妊娠,1例改用其他方法),除5例因
Norplant ~ R is a long-term embedded contraceptive containing only progestin (L-18 A abbreviation LNg), which has no side effect due to estrogen without estrogen and has the characteristics of high efficiency and slow release of low dose, To ensure a longer plasma concentration stability, to avoid fluctuations caused by oral administration of steroids plasma concentration. Long-term application of Norplant ~ R no blood LNg level of accumulation, indicating that the metabolic clearance rate greater than the release rate. The purpose of this study was to determine the time required for ovulation recovery after Norplant ~ R removal. The study included 10 women aged 31.9 ± 5.6 years (23-39) with a mean of 4 ± 2.3 (2-7) births and a mean body weight of 68.0 ± 16 kg (57-107). Norplant-R implanted subcutaneously was 26.2 ± 7.3 Month (11 ~ 36), 6 cases of each implant, each capsule length 3cm, containing LNg34 ± 2mg. Ten cases were irregular menstruation removed in 5 cases (3 cases of menorrhagia, 1 case of breakthrough bleeding, amenorrhea in 1 case), 2 cases of sustained headache, the remaining 3 cases due to non-medical reasons (2 cases of pregnancy, 1 case changed to other methods), except for 5 cases