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目的:评价埃索美拉唑联合莫沙比利治疗胃食管反流性咳嗽的疗效。方法:42例胃食管反流性咳嗽患者随机分为2组,A组23例,给予埃索美拉唑20 mg/次,2次/d,口服;B组19例,给予埃索美拉唑20 mg/次,2次/d,联合莫沙比利5 mg/次,3次/d,口服。8周后按反流性疾病诊断问卷评分标准的模式对咳嗽、烧心、反酸、胸骨后疼痛进行症状评分,比较治疗前、后2组症状改善率及食管炎治愈率。结果:2组治疗后临床症状评分均较治疗前降低(P<0.05),2组治疗后临床症状评分比较差异无统计学意义(P>0.05),但烧心及反酸症状改善B组优于A组(P<0.05);食管炎疗效B组优于A组(P<0.05)。结论:埃索美拉唑可以改善胃食管反流性咳嗽患者的临床症状,联合莫沙比利治疗对临床症状的缓解优于单独应用埃索美拉唑治疗。
Objective: To evaluate the efficacy of esomeprazole combined with mosapride in the treatment of gastroesophageal reflux cough. Methods: Forty-two patients with gastroesophageal reflux disease and cough were randomly divided into two groups: 23 patients in group A received esomeprazole 20 mg once daily for 2 times daily; group B, 19 patients received esomeramide Azole 20 mg / time, 2 times / d, combined with mosapride 5 mg / time, 3 times / d, orally. Eight weeks later, the symptom scores of cough, heartburn, acid reflux, and sternum pain were scored according to the standard of the reflux disease diagnosis questionnaire scale. The symptom improvement rate and esophagitis cure rate of the two groups before and after treatment were compared. Results: The scores of clinical symptoms in both groups were significantly lower than those before treatment (P <0.05). There was no significant difference in clinical symptom score between the two groups after treatment (P> 0.05), but the improvement of heartburn and acid reflux symptoms in group B was better than Group A (P <0.05). The efficacy of esophagitis in group B was better than that in group A (P <0.05). Conclusion: Esomeprazole can improve the clinical symptoms of patients with gastroesophageal reflux cough. The combined treatment with mosapride is superior to esomeprazole alone in relieving clinical symptoms.