在美国食品和药物管理局准许范围内,我们用小鼠抗黑素瘤单克隆抗体与蓖麻毒蛋白A链组成的免疫毒素对患转移性恶性黑素瘤的病人进行了XOMAZYME-MEL~(P)的Ⅰ期临床试验,对22例病人进行了评价。免疫毒素的用量为0.01mg/kg/天,用5天,然后1mg/kg/天,用4天(总剂量3.2～300mg)。多数病人的副作用是血清白蛋白和血清总蛋白降 With the permission of the U.S. Food and Drug Administration, we used XOMAZYME-MEL~ for patients with metastatic malignant melanoma using an immunotoxin consisting of mouse anti-melanoma mAb and ricin A chain. Phase I clinical trials of P) evaluated 22 patients. The immunotoxin was used in an amount of 0.01 mg/kg/day for 5 days and then 1 mg/kg/day for 4 days (total dose of 3.2 to 300 mg). The side effects of most patients are serum albumin and total serum protein