用流式细胞仪及ＡｇＮＯＲ染色方法对比研究了１１３例皮肤良、恶性肿瘤。发现良性肿瘤组与癌前病变组细胞ＤＮＡ均为整倍体，但癌前病变组Ｓ细胞比率较良性肿瘤明显增高。四种恶性肿瘤ＤＮＡ异倍体率为４２．４％～８６．５％。各组样本ＡｇＮＯＲ颗粒数和ＡｇＮＯＲ的异形率与ＤＮＡ指数（ＤＩ）间呈良好正相关。提示用ＤＩ及ＡｇＮＯＲ异形率两指标可从不同角度反映细胞增殖分化程度。 The flow cytometer and AgNOR staining methods were used to compare 113 cases of benign and malignant cutaneous tumors. It was found that the benign tumor group and the precancerous lesion group were all ploidy, but the pre-cancerous lesion group had a significantly higher ratio of S cells than benign tumors. The heteroploidy rate of the four malignant tumors was 42.4%-86.5%. There was a positive correlation between AgNOR particle count and AgNOR heteromorphism and DNA index (DI) in each group. The use of DI and AgNOR profile rates can reflect the extent of cell proliferation and differentiation from different perspectives.