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本文对辽宁省城乡 15 5例唇腭裂病残儿进行流行病学调查 ,结果表明 ,唇腭裂疾病的再发风险率为 3 5 7% ;病残儿母亲有 12 38%既往不良妊娠史、本次先兆流产 9 0 3%、31 6 1%妊娠并发症、19 35 %孕期接触理化环境、34 19%孕期感染、2 6 45 %孕期服药 ;病残儿父亲 19 35 %接触理化环境、8 38%感染、1 94%长期服药。经与后天伤残对照组进行单因素和多因素回归分析 ,遗传因素、患儿母亲孕期母亲用药、孕期父母患感染是导致唇腭裂的主要危险因素。
In this paper, 155 cases of cleft lip and palate were investigated in urban and rural areas in Liaoning Province. The results showed that the risk of recurrent cleft lip and palate was 35.7%. The number of disabled mothers was 12 38% Secondary threatened abortion 9 0 3%, 31 6 1% Complications of pregnancy, 19 35% Exposure to physical and chemical environment during pregnancy, 34 19% Pregnancy infection, 26 45% Pregnancy medication; disabled father 19 35% Physical and chemical environment exposure 8 38 % Infection, 1 94% Long-term medication. Univariate and multivariate regression analysis showed that genetic factors, mothers ’mothers’ mothers during pregnancy, and infection during pregnancy were the main risk factors for cleft lip and palate.