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目的：探讨了肺癌患者手术治疗前后血清CEA、SA、OPN和VEGF水平的变化及临床意义。方法：应用放射免疫分析法、生化法和酶联法对32例肺癌患者进行了手术治疗前后血清CEA、SA、OPN和VEGF水平检测，并与35名正常健康人作比较。结果：肺癌患者在手术治疗前血清CEA、SA、OPN和VEGF水平均非常显著地高于正常人组(P0.05)。结论：检测肺癌患者手术治疗前后血清CEA、SA、OPN和VEGF水平的变化对了解病情、观察疗效和预后判断均具有一定的临床实用价值。“,”objective:To explore clinical Significance of determination of changes of Serum CEA、SA、OPN and VEGF levels after operative in patients with lung cancer. Methods:SerumceA (withRIA).Serum SA(with Biochemistry).Serum OPN.VEGF (with EliSA) levels were determined in 32 patients with lung Cancer both before and after operative as wel as in 35 controls. Results:Before operative.serum CEA、SA、OPN and VEGF levels were significantly higher than those in controls(p0.05).conclusions:Detection of serum CEA、SA、OPN and VEGF levels is clinical y useful for monitoring propress and favourable prognosis of patients with lung cancer possess important clinical values.