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目的:分析多发性骨髓瘤校正血钙的临床意义。方法:检测98例初发骨髓瘤患者的血钙水平,用同时采集静脉血所得血清白蛋白浓度分别带入两个公式进行校正,比较校正前后及两个校正值的血钙水平。结果:经两个公式校正后高钙血症发生率比校正前均显著升高(P<0.01),经公式1和2校正后的两组高钙血症无显著性差异。多发性骨髓瘤Ⅰ期患者血钙水平校正前为(2.249±0.073)mmol/L,经公式1校正后为(2.324±0.132)mmol/L,经公式2校正后为(2.389±0.106),校正前后及校正后的两组值之间均无显著差异(P>0.05)。Ⅱ期患者血钙水平校正前为(2.263±0.272)mmol/L,经公式1校正后为(2.510±0.259)mmol/L,经公式2校正后为(2.453±0.258),校正前与两组校正后数值均有显著性差异(P<0.01),校正后的两组值之间无显著差异(P>0.05)。Ⅲ期患者血钙水平校正前为(2.379±0.392)mmol/L,经公式1校正后为(2.584±0.422)mmol/L,经公式2校正后为(2.531±0.416),校正前与两组校正后数值均有显著性差异(P<0.01),校正后的两组值之间无显著差异(P>0.05)。A、B两组骨髓瘤患者血钙浓度具有显著性差异(P<0.01),校正后的两组值之间无显著差异(P>0.05)。结论:本文所选患者中经白蛋白校正的高血钙的发生率,与国外文献报道并不低。校正血钙更敏感地反映疾病的严重程度,高血钙与肾功能不全存在相关性,两个校正公式校正血钙值无差异。
Objective: To analyze the clinical significance of correcting serum calcium in multiple myeloma. Methods: The blood calcium levels of 98 patients with primary myeloma were detected. The serum albumin concentrations of the patients with primary myeloma were detected by two formulas. The levels of serum calcium were compared before and after the correction and the two corrected values. Results: The incidence of hypercalcaemia after correction by both formulas was significantly higher than that before correction (P <0.01). There was no significant difference between the two groups of hypercalcemia corrected by formulas 1 and 2. The level of serum calcium in patients with multiple myeloma was (2.249 ± 0.073) mmol / L before correction of serum calcium (2.324 ± 0.132) mmol / L after correction by formula 1, and was 2.389 ± 0.106 after correction by formula 2 There was no significant difference between the two groups before and after and after correction (P> 0.05). The level of serum calcium was (2.263 ± 0.272) mmol / L before adjustment in patients of stage Ⅱ, and was (2.510 ± 0.259) mmol / L after adjustment of formula 1, (2.453 ± 0.258) after adjustment of formula 2, The corrected values were significantly different (P <0.01). There was no significant difference between the two groups after correction (P> 0.05). The level of serum calcium was (2.379 ± 0.392) mmol / L before treatment in patients with stage Ⅲ, and was (2.584 ± 0.422) mmol / L after the correction by equation 1. The corrected level was (2.531 ± 0.416) The corrected values were significantly different (P <0.01). There was no significant difference between the two groups after correction (P> 0.05). There was a significant difference in serum calcium concentrations between A and B groups (P <0.01). There was no significant difference between the two groups (P> 0.05). CONCLUSIONS: The incidence of hypercalcemia corrected for albumin in the patients selected for this study is not low reported in foreign literature. Correction of serum calcium more sensitive to reflect the severity of the disease, hypercalcemia and renal insufficiency there is a correlation between the two correction formula to correct blood calcium no difference.