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目的:评价高压氧对新生儿缺氧缺血性脑病(HIE)的疗效及预后,为临床治疗提供参考依据。方法:将92例患儿随机分为治疗组和对照组,两组均给予常规治疗,治疗组加用高压氧治疗,对两组患儿治疗后主要临床症状恢复的时间、临床疗效及预后进行观察和随访。结果:治疗组的意识状态、原始反射、肌张力、前囟张力、呼吸、面色恢复正常需要的时间显著低于对照组(P(0.01);治疗组临床疗效显著优于对照组(P(0.05);随访结果,治疗组的后遗症显著低于对照组(P(0.01)。结论:高压氧治疗对新生儿缺氧缺血性脑病有明显的临床治疗作用并能明显减少后遗症的发生。
Objective: To evaluate the effect and prognosis of hyperbaric oxygen on neonatal hypoxic-ischemic encephalopathy (HIE) and provide a reference for clinical treatment. Methods: Ninety-two children were randomly divided into treatment group and control group. Both groups were given conventional therapy. The treatment group was treated with hyperbaric oxygen therapy. The recovery time, clinical efficacy and prognosis of the main clinical symptoms of the two groups were compared Observation and follow-up. Results: The time required for the patients to feel consciousness, original reflex, muscular tension, anterior fontanelle, respiration and complexion returned to normal was significantly lower than that of the control group (P <0.01). The clinical efficacy of the treatment group was significantly better than that of the control group ). The follow-up results showed that the sequelae of the treatment group were significantly lower than those of the control group (P <0.01) .Conclusion: Hyperbaric oxygen therapy has obvious clinical therapeutic effect on neonatal hypoxic-ischemic encephalopathy and can significantly reduce the occurrence of sequelae.