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目的探讨nm23H1基因表达和sIL-2R水平变化在儿童急性淋巴细胞白血病(ALL)中的临床意义。方法用RT-PCR和ELASA法分别检测了42例儿童ALL骨髓细胞nm23H1基因表达情况和血清slL-2R水平。结果儿童ALL初治组nm23H1基因表达阳性率为66%,表达程度明显高于对照组(P<0.01),完全缓解(CR)组表达程度下降,阳性率降低,为10.7%,与正常对照组比较差异无统计学意义(P>0.05)。复发难治组表达明显增高,为71.4%,与初治组比较差异无统计学意义(P>0.05)。sIL-2R水平在初诊组升高,与正常对照组比较差异有统计学意义(P<0.05),CR组sIL-2R水平下降,复发时再次升高。观察nm23H1基因表达阳性组和阴性组sIL-2R水平,发现阳性组sIL-2R呈高水平,追踪治疗反应该组CR率低,易复发。结论nm23H1基因表达和sIL-2R水平在儿童ALL疾病发展过程中有明显变化,有助于判断儿童ALL疾病期和预示复发,高表达的nm23H1和高水平的sIL-2R是否与难治复发有关,有待进一步扩大样本研究。
Objective To investigate the clinical significance of nm23H1 gene expression and sIL-2R level in childhood acute lymphoblastic leukemia (ALL). Methods The expressions of nm23H1 gene and serum slL-2R in 42 cases of children with ALL were detected by RT-PCR and ELASA. Results The positive rate of nm23H1 gene expression in children with ALL was 66%, which was significantly higher than that in control group (P <0.01). The expression of nm23H1 in complete remission (CR) group was lower than that in control group (10.7% The difference was not statistically significant (P> 0.05). Recurrence and refractory group expression was significantly higher, 71.4%, compared with the initial treatment group was no significant difference (P> 0.05). The level of sIL-2R in the newly diagnosed group was significantly higher than that in the normal control group (P <0.05). The level of sIL-2R in CR group was decreased and increased again at the time of relapse. The level of sIL-2R in positive group and negative group of nm23H1 gene was observed. The level of sIL-2R in the positive group was high, and the CR rate in the positive group was low. Conclusion The expression of nm23H1 gene and the level of sIL-2R in children with ALL have significant changes during the development of childhood ALL. It is helpful to determine whether the relapse and relapse of childhood ALL have high expression of nm23H1 and sIL-2R. To be further expanded sample study.