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本文探讨儿童慢性扁桃体炎患者外周血ＩｇＧ＿４、可溶性白细胞介素受体２（ｓＩＬ－２Ｒ）与病变程度的关系。５１例患者分为３组，第一组为偶发炎症组１５例（对照组），第二组为频发炎症组２３例，第三组为病灶组１３例，检测每例患儿外周血的ＩｇＧ＿４和ｓＩＬ－２Ｒ的水平，并将第二、三组的数值与第一组进行统计学对比处理。结果表明，第一组的ｓＩＬ－２Ｒ为１７２．２±４８．０ｕ／ｍｌ，ＩｇＧ，为６６．４±４５．７μｇ／ｍｌ。第二组的ＩｇＧ＿４（３５７．５±１６８．７μｇ／ｍｌ）及第三组的ｓＩＬ－２Ｒ（３９９．６±１５３．４ｕ／ｍｌ）均明显高于第一组（Ｐ＜０．０１），第二组的ｓＩＬ－２Ｒ（２２６．１±８１．７ｕ／ｍｌ）亦高于第一组（Ｐ＜０．０５），而第三组的ＩｇＧ＿４（５２．７±６０．５μｇ／ｍｌ）则与第一组无明显差异（Ｐ＞０．０５）。这说明儿童慢性扁桃体炎免疫功能的改变与细菌、病毒等抗原刺激扁桃体的频度有关。通过检测外周血的ＩｇＧ＿４和ｓＩＬ－２Ｒ，了解患者的免疫状态和疾病的程度对诊断和治疗有一定临床意义。
This article explores the relationship between IgG_4 and soluble interleukin 2 receptor (sIL-2R) in peripheral blood and pathological changes in children with chronic tonsillitis. 51 patients were divided into 3 groups, the first group of 15 cases of infrequent inflammation group (control group), the second group of 23 cases of frequent inflammation group, the third group of 13 cases of lesions, the detection of peripheral blood in each case IgG4 and sIL-2R levels, and the second and third groups of values were statistically compared with the first group. The results showed that the sIL-2R of the first group was 172.2 ± 48.0 u / ml and the IgG was 66.4 ± 45.7 μg / ml. IgG3 (357.5 ± 168.7μg / ml) and sIL-2R (399.6 ± 153.4u / ml) in the second group were significantly higher than those in the first group (P <0.01) The sIL-2R in the second group (226.1 ± 81.7u / ml) was also higher than in the first group (P <0.05), whereas the third group had IgG 4 (52.7 ± 60.5μg / ml) No significant difference with the first group (P> 0.05). This shows that children with chronic tonsillitis immune function changes and bacteria, viruses and other antigens to stimulate the frequency of tonsils related. Through the detection of peripheral blood IgG_4 and sIL-2R, to understand the patient’s immune status and the extent of the disease for the diagnosis and treatment of certain clinical significance.