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目的:探讨氟尿嘧啶和亚叶酸钙联合奧沙利珀治疗晚期胃癌的近期疗效及毒副作用。方法:从2010年9月～2012年10月,采用氟尿嘧啶500mg/m~2静滴>3小时,第1天～第5天。亚叶酸钙50 mg/m~2静滴第1天～第5天,奥沙利珀130 mg/m~2静滴>2小时,第1天。每21天重复。治疗2～4周期按WHO实体瘤疗效评定标准评价疗效及毒副反应。结果:全组26例确诊为晚期胃癌。其中CR 1例,PR 10例,SD 6例,PD 7例。近期疗效(CR+PR)42.3%。肿瘤控制率DCR为65.3%。中位生存期7.5个月。胃肠道反应、骨髓抑制和末梢神经毒性是主要的毒副反应。无化疗相关性死亡。结论:氟尿嘧啶和亚叶酸钙联合奥沙利珀治疗晚期胃癌有效率及肿瘤控制率较高,毒副反应低,是治疗晚期胃癌的较好方案之一。
Objective: To investigate the short-term curative effect and toxicity of fluorouracil and leucovorin in combination with oxaliplatin in the treatment of advanced gastric cancer. Methods: From September 2010 to October 2012, intravenous infusion of fluorouracil 500 mg / m 2 was administered for> 3 hours from day 1 to day 5. Calcium leucovorin 50 mg / m ~ 2 intravenous infusion from day 1 to day 5, oxalipa 130 mg / m ~ 2 intravenous infusion> 2 hours on the first day. Repeat every 21 days. Treatment 2 to 4 cycles according to WHO solid tumor efficacy evaluation criteria to evaluate the efficacy and toxicity. Results: The whole group of 26 patients diagnosed with advanced gastric cancer. Among them CR 1 cases, PR 10 cases, SD 6 cases, PD 7 cases. Short-term efficacy (CR + PR) 42.3%. The tumor control rate DCR was 65.3%. The median survival of 7.5 months. Gastrointestinal reactions, myelosuppression and peripheral neurotoxicity are the major side effects. No chemotherapy-related death. Conclusion: The combination of fluorouracil and leucovorin with oxaliplatin in the treatment of advanced gastric cancer has high efficiency, high tumor control rate and low toxicity. It is one of the better regimens for the treatment of advanced gastric cancer.