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islet－1基因是同源框基因LIM家族的一员。LIM同源框基因在中枢神经系统中的作用引起了人们越来越多的关注。本文作者等采用免疫组织化学ABC法研究了同源框基因islet－1的表达产物（ISL－1）在大鼠海马中的分布，结果表明ISL－1广泛分布于成年大鼠海马各区的神经元内。鉴于同源框基因的表达产物主要为参与基因的表达调控，提示该基因与成年大鼠海马神经元的基因表达调控有着密切的关系。
The islet-1 gene is a member of the homeobox gene LIM family. The role of LIM homeobox genes in the central nervous system has attracted more and more attention. The authors used immunohistochemical ABC method to study the distribution of islet-1 expression product (ISL-1) in rat hippocampus. The results showed that ISL-1 is widely distributed in neurons of hippocampus of adult rats Inside. In view of the fact that the expression product of the homeobox gene is mainly involved in the gene expression regulation, this gene is closely related to the gene expression regulation of hippocampal neurons in adult rats.