目的观察小剂量固尔苏联合鼻塞式持续气道正压通气(nCPAP)预防早产儿呼吸窘迫综合征(NRDS)的临床效果。方法将高危早产儿230例随机分为观察组120例和对照组110例。观察组采用小剂量固尔苏联合nCPAP,对照组采用nCPAP。观察2组早产儿的血气分析改善情况,NRDS发生率、病死率及住院时间。结果用药后观察组动脉血氧分压(PaO2)、pH值及动脉血氧饱和度(SaO2)高于对照组,血二氧化碳分压(PaCO2)低于对照组,NRDS发生率、病死率均低于对照组,住院时间均短于对照组,差异均有统计学意义(P<0.05)。结论早期应用小剂量固尔苏联合nCPAP预防高危早产儿NRDS效果较好,可有效改善血气指标,降低NRDS发生率及病死率,缩短住院时间,值得临床推广应用。 Objective To observe the clinical effect of small dose of Coult-Su and nasal continuous positive airway pressure (nCPAP) in preventing respiratory distress syndrome (NRDS) in preterm infants. Methods 230 cases of high risk premature children were randomly divided into observation group of 120 cases and control group of 110 cases. The observation group used small dose of cortisol combined nCPAP, the control group used nCPAP. Blood gas analysis was observed in two groups of premature children to improve the situation, NRDS incidence, mortality and length of stay. Results PaO2, pH value and arterial oxygen saturation (SaO2) in the observation group were higher than those in the control group after treatment. The PaCO2 of the observation group was lower than that of the control group. The incidence of NRDS and the mortality rate were all lower In the control group, the length of hospital stay was shorter than that in the control group, with significant differences (P <0.05). Conclusion Early use of small dose of cortisol combined with nCPAP prevent NRDS in high-risk high preterm children is better, which can effectively improve blood gas index, reduce the incidence of NRDS and mortality, shorten the hospital stay, worthy of clinical application.