1958年 Bouroncle 等首次描述了 HCL,但仅在近12年人们才对 HCL 进行了详细的研究。应该强调的是大部分病人在诊断时就有全血细胞减少或多细胞系减少,其原因是脾滞血及骨髓中正常血细胞生成低下。HCL 的治疗指征包括:严重贫血血细胞压积<25％;血小板数<50 000/μl;粒细胞绝 HCL was first described in 1958 by Bouroncle et al., But HCL was studied in detail only in the last 12 years. It should be emphasized that most patients have pancytopenia or multiple cell lines at the time of diagnosis due to splenic blood loss and low normal blood cell production in the bone marrow. Indications for HCL include: severe anemia, hematocrit <25%, platelet count <50,000 / μl, neutrophil