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目的 :探讨新生儿窒息后血浆β-内啡呔 (β- EP)、β2 -微球蛋白 (β2 - MG)浓度的变化与脑、肾损伤的关系。方法 :用放射免疫法监测窒息新生儿重度组 15例、轻度组 12例和对照组 10例血浆β- EP、β2 - MG的浓度 ,分别于生后 8～ 12 h、72～ 96 h采血两次。 结果 :窒息组 β- EP、β2 - MG值均明显增高 ,经方差分析各组间存在总体差异 (P<0 .0 1～ 0 .0 0 1)。经 q检验 ,8～ 12 h轻度组与对照组比较 ,P <0 .0 1～ 0 .0 0 1;重度组与轻度组比较 ,P <0 .0 0 1。脑病组与非脑病组 β- EP值比较 ,P <0 .0 0 1。 结论 :新生儿窒息可致 β- EP、β2 - MG值增高 ,且与窒息程度有关。 β-EP可能参与并加重了脑损伤的病理生理过程。β2 - MG的浓度变化 ,对早期反映窒息后引起肾小球滤过率障碍较为敏感 ,与肾功能损伤程度有关
Objective: To investigate the relationship between changes of plasma β-endorphin (β-EP) and β2-microglobulin (β2-MG) and brain and kidney damage after neonatal asphyxia. Methods: The levels of plasma β - EP and β2 - MG in 15 severe neonatal asphyxia group, 12 mild group and 10 normal control group were measured by radioimmunoassay. Blood samples were taken from 8 to 12 h and from 72 to 96 h after birth twice. Results: The levels of β - EP and β2 - MG in asphyxia group were significantly higher than those in control group (P <0.01 ~ 0.010). By q test, 8 ~ 12 h mild group compared with the control group, P <0 1 ~ 0. 0 0 1; severe group and mild group, P <0. Encephalopathy group and non-encephalopathy group β-EP value, P <0. Conclusion: Neonatal asphyxia can cause β - EP, β2 - MG increased, and the degree of asphyxia. β-EP may participate in and aggravate the pathophysiology of brain injury. The change of β2 - MG concentration is sensitive to the glomerular filtration rate disturbance caused by asphyxia in early stage, and the degree of renal dysfunction