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目的:评价甲状腺功能亢进(甲亢)合并心房颤动(房颤)患者发生缺血性脑卒中的风险。方法:回顾性分析甲亢合并新发房颤且无其他合并症、既往无脑卒中史患者34例(甲亢合并房颤组)的临床资料,选取年龄、性别相匹配且无并发症、脑卒中史的甲亢不合并房颤(甲亢组)及新发孤立性房颤者(房颤组)各34例作为对照。进行临床和电话随访,分析房颤复律及缺血性脑卒中发生情况。结果:甲亢合并房颤组20例(59.0%)、房颤组21例(62.0%)自发或通过药物转复并维持稳定的窦性心律,2组之间差异无统计学意义(P>0.05);甲亢合并房颤组3例(8.8%)、房颤组1例(2.9%)发生缺血性脑卒中,2组比较,P<0.05;甲亢合并房颤组、房颤组、甲亢组发生缺血性脑卒中者分别为3例、1例、0例。结论:甲亢合并房颤患者缺血性脑卒中风险较高,可能与甲亢增加了房颤机体的高凝状态有关。
PURPOSE: To evaluate the risk of ischemic stroke in patients with hyperthyroidism (Hyperthyroidism) and atrial fibrillation (AF). Methods: The clinical data of 34 patients with hyperthyroidism complicated with new onset of atrial fibrillation and no other comorbidities and without history of stroke were retrospectively analyzed. Age, sex matched without complications, history of stroke Of hyperthyroidism without atrial fibrillation (hyperthyroidism group) and new cases of isolated atrial fibrillation (atrial fibrillation group) of 34 cases as a control. Clinical and telephone follow-up, analysis of atrial fibrillation and ischemic stroke occurred. Results: Twenty patients (59.0%) with hyperthyroidism complicated with atrial fibrillation and 21 patients (62.0%) with atrial fibrillation had spontaneous or drug-stable sinus rhythm. There was no significant difference between the two groups (P> 0.05 ); Hyperthyroidism with atrial fibrillation in 3 cases (8.8%), AF in 1 case (2.9%) ischemic stroke, the two groups were compared, P <0.05; hyperthyroidism with atrial fibrillation group, atrial fibrillation group, hyperthyroidism group The incidence of ischemic stroke were 3 cases, 1 case, 0 cases. Conclusion: Hyperthyroidism with atrial fibrillation in patients with high risk of ischemic stroke may be associated with increased hyperthyroidism hyperkeratosis state of atrial fibrillation body.