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目的评价“川椒方”治疗过敏性鼻结膜炎的有效性。方法前瞻性研究,双盲双模拟平行对照设计。将符合纳入标准的122例过敏性鼻结膜炎患者随机分为治疗组(口服川椒方颗粒及西替利嗪安慰剂)和对照组(口服西替利嗪胶囊及川椒方安慰剂),治疗2周,观察2组患者治疗1周及治疗2周后的眼、鼻部症状、体征评分变化。结果完成治疗及随访者102例,川椒方治疗组53例,对照组49例,2组的一般资料及治疗前的症状、体征评分差异均无统计学意义(P>0.05)。治疗1周后,2组眼部、鼻部评分均较前下降(P<0.05),组间差异均无统计学意义(P>0.05)。治疗2周后,2组眼部、鼻部评分较治疗后1周时进一步下降(P<0.05),治疗组的眼部各症状、体征评分低于对照组(P<0.05),鼻部各评分与对照组接近(P>0.05)。结论川椒方“目鼻同治”治疗过敏性鼻结膜炎有效。
Objective To evaluate the effectiveness of Chuanjiao Prescription in the treatment of allergic rhinoconjunctivitis. Methods Prospective study, double-blind, double-model parallel control design. The 122 patients with allergic rhinoconjunctivitis who met the inclusion criteria were randomly divided into treatment group (oral Chuanjiao Fang granules and cetirizine placebo) and control group (oral cetirizine capsules and chuanjiao Fang placebo), treatment Two weeks later, the changes of ocular and nasal symptoms and signs in two groups were observed after one week of treatment and two weeks after treatment. Results There were no significant differences between the two groups (102 cases, 53 cases treated with Chuanjiao Recipe, 49 cases treated with Chuan Jiao decoction and the control group), and no difference in symptoms and signs before treatment (P> 0.05). After 1 week of treatment, the scores of both eyes and nose in both groups were significantly lower than those before (P <0.05). There was no significant difference between the two groups (P> 0.05). After 2 weeks of treatment, the ocular and nasal scores of the two groups were further decreased (P <0.05) compared with those of the control group after 1 week of treatment. The symptoms and signs of the eyes in the treatment group were lower than those of the control group (P <0.05) Score and control group close (P> 0.05). Conclusion Chuanjiao Fang “Head and nose Tongzhi ” treatment of allergic rhinoconjunctivitis effective.