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目的探讨血小板活化及凝血功能检测在川崎病(KD)诊疗中的意义。方法收集川崎病患儿40例于治疗前及治疗后检测平均血小板内容物浓度(MPC)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)、凝血酶时间(TT)、凝血酶原时间(PT);40例健康儿童为对照组。结果 KD组患儿治疗前及治疗后MPC水平显著低于正常对照组(P<0.05)。KD组患儿治疗前FIB水平显著高于正常对照组(P<0.05),治疗后FIB水平回复正常(P>0.05)。其余结果比较,差异均无统计学意义(P>0.05)。结论 FIB与活化的血小板相互作用促进了KD急性冠状动脉血栓的形成。KD治疗前MPC降低和FIB增高可作为KD早期辅助诊断的重要指标。在KD诊疗中观测MPC与FIB水平有助于临床及时了解病情,判断预后及转归。
Objective To investigate the significance of platelet activation and coagulation testing in diagnosis and treatment of Kawasaki disease (KD). Methods Forty children with Kawasaki disease were enrolled in this study. Mean thromboplastin concentration (MPC), activated partial thromboplastin time (APTT), fibrinogen (FIB), thrombin time (TT), thrombin The original time (PT); 40 healthy children as the control group. Results The levels of MPC in KD group before and after treatment were significantly lower than those in normal control group (P <0.05). The FIB level in KD group before treatment was significantly higher than that in normal control group (P <0.05), and the FIB level returned to normal after treatment (P> 0.05). The rest of the results were compared, the difference was not statistically significant (P> 0.05). Conclusion The interaction of FIB with activated platelets promotes the formation of KD acute coronary thrombosis. KD decreased MPC before treatment and increased FIB can be used as an important indicator of early diagnosis of KD. To observe the MPC and FIB levels in the diagnosis and treatment of KD is helpful for clinical understanding of the disease in time, and prognosis and prognosis.