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食管癌是人类最常见的恶性肿瘤之一,死亡率位居我国恶性肿瘤第4位。食管癌主要有2种病理类型:食管腺癌与食管鳞状细胞癌,在我国多为食管鳞癌。目前关于食管鳞癌的病理机制尚未完全明确。长链非编码RNA(lnc RNA)是指长度大于200个碱基的无编码蛋白能力的RNA。研究发现lnc RNA可以在多个水平参与基因表达调控,进而影响食管鳞癌发生发展及重要生物学过程。通过归纳总结lnc RNA在食管鳞癌中病理机制的文献报道,以期为将lnc RNA开发成食管鳞癌的新型诊断标记物以及作为治疗靶点进行药物研发提供重要参考。
Esophageal cancer is one of the most common human malignant tumors, the mortality rate ranked the 4th in China. Esophageal cancer has two main pathological types: esophageal adenocarcinoma and esophageal squamous cell carcinoma, mostly in our country esophageal squamous cell carcinoma. The pathological mechanism of esophageal squamous cell carcinoma is not yet completely clear. Long chain non-coding RNAs (lnc RNAs) refer to non-coding protein-capable RNAs that are greater than 200 bases in length. The study found that lnc RNA can participate in gene expression regulation at many levels, and then affect the occurrence and development of esophageal squamous cell carcinoma and important biological processes. To summarize the lnc RNA pathological mechanism in esophageal squamous cell carcinoma reported in the literature, in order to develop lnc RNA into esophageal squamous cell carcinoma of the new diagnostic markers and as a therapeutic target for drug development provides an important reference.