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左旋咪唑(Levamisole,简称LMS)系四咪唑(驱虫净)的左旋体,化学名为L—2,3,5,6-四氢-6-苯基咪唑(2,1—6)噻唑,国外商品名为Ketrax。LMS是一种白色结晶体,在空气中稳定,易溶于水、甲醇和甘油,难溶于氯仿、乙醚和丙酮。小白鼠口服的半数致死量为290毫克/公斤。LMS原系一种广谱驱虫药,国外自1966年以来,用于驱除肠道线虫,近年来发现LMS可增强机体的免疫能力,已较广泛地试用于肿瘤、病毒性疾病、细菌性疾病、结缔组织疾病和其他一些疾病的治疗,获得可喜的效果。现将有关资料作一初步综合介绍,以供参考。
Levamisole (LMS) is a levamisole of tetraimidazole (deworming net) chemically named L-2,3,5,6-tetrahydro-6-phenylimidazole (2,1-6) thiazole, Foreign trade name Ketrax. LMS is a white crystalline, stable in air, soluble in water, methanol and glycerol, insoluble in chloroform, ether and acetone. The oral LD50 of mice is 290 mg / kg. LMS was originally a broad-spectrum deworming drug. Since 1966, LMS has been used to repel intestinal nematodes. In recent years, it has been found that LMS can enhance the immunity of the body and has been widely tested in tumors, viral diseases, bacterial diseases , Connective tissue diseases and other diseases, to obtain gratifying results. Now the information for a preliminary comprehensive introduction for reference.