目的探讨盐酸美金刚治疗帕金森痴呆的近期临床效果。方法选择帕金森痴呆患者46例,按治疗方法分为A组和B组各23例。A组采用盐酸美金刚治疗,B组采用左旋多巴治疗,观察2组治疗后简易智能状态检查量表(MMSE)和蒙特利尔认知量表(Mo CA)的评分,评价日常生活能力。结果 A组治疗4、8、12周MMSE和Mo CA评分高于B组,生活能力优于B组(P<0.05)。结论盐酸美金刚治疗帕金森痴呆近期临床效果显著,可提高患者生活能力。 Objective To investigate the recent clinical effects of memantine hydrochloride in the treatment of Parkinson’s dementia. METHODS: Forty-six patients with Parkinson’s dementia were divided into two groups according to the treatment: group A and group B, with 23 cases each. Group A was treated with memantine hydrochloride. Group B was treated with levodopa. The scores of MMSE and Mo CA were compared between two groups to evaluate the daily living ability. Results The scores of MMSE and Mo CA in group A at 4, 8 and 12 weeks were higher than those in group B, and the viability of group A was better than that of group B (P <0.05). Conclusion The recent clinical effect of memantine hydrochloride in treating Parkinson’s dementia is significant, which can improve the living ability of patients.