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奥美拉唑是瑞典阿斯特拉Hassle公司1979年发现的苯并咪唑衍生物,为一个在胃酸分泌最终阶段,选择性地阻碍作为质子泵作用的酶(H~+-K~+)ATPase,而具有强力、持续的胃酸分泌抑制作用的化合物。作为质子泵阻滞剂,期待其有优于H_2受体拮抗剂的抗溃疡效果而进行开发,结果不仅是对消化性溃疡,对返流性食道炎、吻合部溃疡、Zollinger-Ellison症候群亦显示优越的治疗效果。目
Omeprazole is a benzimidazole derivative discovered in 1979 by Astra Hassle, Sweden. It is an enzyme (H~+-K~+) ATPase that selectively blocks the action of proton pumping in the final stage of gastric acid secretion. , and compounds that have strong, sustained inhibition of gastric acid secretion. As a proton pump blocker, development is expected to have an anti-ulcer effect superior to that of H_2 receptor antagonists. The result is not only for peptic ulcers, but also for reflux esophagitis, anastomotic ulcers, and Zollinger-Ellison syndrome. Superior therapeutic effect. Head