【摘 要】
：
DE-ETIOLATED1(DET1)and CONSTITUTIVE PHOTOMORPHOGENESIS1(COP1)are two essential repres-sors of Arabidopsis photomorphogenesis.These proteins can associate with C
【机 构】
：
Centro Nacional de Biotecnología,CNB-CSIC,Madrid 28049,Spain;Institut de biologie de I’école normale
论文部分内容阅读
DE-ETIOLATED1(DET1)and CONSTITUTIVE PHOTOMORPHOGENESIS1(COP1)are two essential repres-sors of Arabidopsis photomorphogenesis.These proteins can associate with CULLIN4 to form independent CRL4-based E3 ubiquitin ligases that mediate the degradation of several photomorphogenic transcription factors,including ELONGATED HYPOCOTYL 5(HY5),thereby controlling multiple gene-regulatory net-works.Despite extensive biochemical and genetic analyses of their multi-subunit complexes,the func-tional links between DET1 and COP1 have long remained elusive.Here,we report that DET1 associates with COP1 in vivo,enhances COP1-HY5 interaction,and promotes COP1 destabilization in a process that dampens HY5 protein abundance.By regulating its accumulation,DET1 avoids HY5 association with hundreds of second-site genomic loci,which are also frequently targeted by the skotomorphogenic tran-scription factor PHYTOCHROME-INTERACTING FACTOR 3.Accordingly,ectopic HY5 chromatin enrich-ment favors local gene repression and can trigger fusca-like phenotypes.This study therefore shows that DET1-mediated regulation of COP1 stability tunes down the HY5 cistrome,avoiding hyper-photomorphogenic responses that might compromise plant viability.
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