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目的探讨血浆心脏型脂肪酸结合蛋白)H-FABP)在急性心肌梗死(AMI)早期诊断中的临床意义。方法选择因胸痛就诊被确诊为急性心肌梗死患者35例,采用免疫胶体金渗透方法定性检测对照组和患者发病3 h内和12 h后血浆的H-FABP,同时测定心肌肌钙蛋白I(cTnI)、肌酸激酶同工酶(CK-MB),并进行比较。结果H-FABP对AMI发病3 h内的诊断阳性率为90.2%,与其他两项指标比较有统计学差异(P<0.05);而在发病12 h后阳性率为12.3%,明显低于另两项指标。结论H-FABP对于诊断早期AMI具有较高的敏感性和特异性,优于cTnI、CK-MB。
Objective To investigate the clinical significance of plasma cardiac fatty acid binding protein (H-FABP) in the early diagnosis of acute myocardial infarction (AMI). Methods Thirty-five patients with acute myocardial infarction who were diagnosed as having chest pain were selected. H-FABP was detected within 3 h and 12 h after the onset of the disease by immunogold permeation assay. The levels of cardiac troponin I (cTnI ), Creatine kinase isoenzyme (CK-MB), and compared. Results The positive rate of H-FABP in diagnosing AMI within 3 hours was 90.2%, which was significantly different from the other two indexes (P <0.05). The positive rate of H-FABP after 12 hours was 12.3% Two indicators. Conclusion H-FABP has higher sensitivity and specificity for the diagnosis of early AMI than cTnI and CK-MB.