华支睾吸虫病在我省珠江三角洲和潮汕一带流行已久,感染率自7.8～88.6%之间。近年来通过调查,证实梅县、韶关和肇庆地区均有本病流行,广州市和惠阳地区甚至海南岛亦不断有病例报告,并有死亡病例发生,说明华支睾吸虫病是严重危害我省人民健康的一种地方性流行病。由于华支睾吸虫对许多化学药物不敏感,所以在过去很长时间对本病治疗尚存在着不少困难。各国学者为探索治疗该病的药物,数十年来进行了许多研究,试用过多种化学药物。最初试用的如麝香草脑、苦味酸和龙胆紫等,均未见效 Clonorchis sinensis has long been popular in the Pearl River Delta and Chaoshan in our province, with an infection rate of 7.8% to 88.6%. In recent years, the survey confirmed that Meixian, Shaoguan and Zhaoqing have the disease epidemic, Guangzhou and Huiyang and even Hainan Island have also reported cases and deaths, indicating that clonorchiasis is a serious threat to our people A local epidemic of health. As Clonorchis sinensis is insensitive to many chemicals, there have been many difficulties in the treatment of this disease for a long time in the past. Researchers from various countries have conducted many studies and tried many kinds of chemical drugs for decades to explore the drug for the treatment of the disease. The first trial, such as thyme brain, picric acid and gentian violet, were not effective