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为了寻找不疏水的有效润滑剂,本文拟定了二条评价标准:(1)设计的处方是否可行;(2)制剂的重量差异。用这二条标准研究了十二烷基硫酸镁(MgLS)等润滑剂对所设计的胶囊剂和片剂处方在胶囊填充与压片时的情况以及制得的胶囊剂、片剂的重量差异以及它们的崩解度与溶解速率。设计的四个处方为:LiCO_3胶囊剂处方,应用自动胶囊填充机填装胶囊;两个片剂处方以白陶土为原料,α-纤维素,阿拉伯胶为辅料,用糖浆制粒后在单冲与旋转式压片机上压片;一个直接压片的处方。采用了不同量的MgLS(0.125,0.25,0.5%),硬脂酸镁(MgST)0.065～0.5%,十二烷基硫酸钠(NaLS)0.125～0.5%为润滑剂。这些润滑剂都符
In order to find a non-hydrophobic and effective lubricant, this article has developed two evaluation criteria: (1) the design of the prescription is feasible; (2) the weight difference between formulations. Using these two criteria, we investigated the formulation of capsules and tablets formulated with lubricants such as magnesium lauryl sulfate (MgLS) at the time of capsule filling and tabletting, as well as the weight differences between capsules and tablets prepared and Their degree of disintegration and dissolution rate. The four prescriptions for the design are as follows: LiCO_3 capsule prescription, filling capsules with automatic capsule filling machine; prescription of two tablets using kaolin as raw material, α-cellulose and acacia as auxiliary materials, granulating with syrup, Tableting with a rotary tablet press; a prescription for direct tableting. Different amounts of MgLS (0.125,0.25,0.5%), magnesium stearate (MgST) 0.065-0.5% and sodium lauryl sulfate (NaLS) 0.125-0.5% were used as lubricant. These lubricants all match