Organic photovoltaics and field-effect transistors have attracted considerable attention due to the easy fabrication,low cost,light weight,and flexibility.Unsymmetrical conjugated building blocks are widely utilized for the design of new organic π-functional materials in order to achieve high-performance electronic devices,which has become a hot research topic in recent years.In this review,we summarized some typical organic π-functional materials with regioregular conjugated backbones with unsymmetrical electron-deficiency moieties and focused on the influence of regiochemistry on the final device performance. Organic photovoltaics and field-effect transistors have attracted attention due to the easy fabrication, low cost, light weight, and flexibility. Unymmetrical conjugated building blocks are widely utilized for the design of new organic π-functional materials in order to achieve high-performance electronic devices, which has become a hot research topic in recent years. this review, we summarized some typical organic π-functional materials with regioregular conjugated backbones with unsymmetrical electron-deficiency moieties and focused on the influence of regiochemistry on the final device performance.