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目的：探讨鼻咽泡状核细胞癌（ＶＮＣＣ）和低分化鳞癌（ＰＤＳＣＣ）的临床生物学行为的差异性。方法：用原位杂交和免疫组化染色（ＳＰ法）技术，检测ＶＮＣＣ和ＰＤＳＣＣ癌组织中ＣｅｒｂＢ２、表皮生长因子受体（ＥＧＦＲ）和增殖细胞核抗原（ＰＣＮＡ）表达，用原位末端标记（ＩＳＬＥ）方法检测癌细胞凋亡，并对其预后和临床特征进行对比分析。结果：①ＶＮＣＣ的ＩＳＥＬ和ＰＣＮＡ染色强度指数（ＳＩ）明显高于ＰＤＳＣＣ；②ＶＮＣＣ的ＣｅｒｂＢ２、ＥＧＦＲｍＲＮＡ和ＣｅｒｂＢ２蛋白表达与ＰＤＳＣＣ无明显差别；③ＶＮＣＣ的５年生存率比ＰＤＳＣＣ高。结论：与ＰＤＳＣＣ比较，ＶＮＣＣ是一种生长增殖活跃、分化程度更低，但有较好预后趋向的一种癌型。
Objective: To investigate the difference of clinical biological behavior of nasopharyngeal vesicular carcinoma (VNCC) and poorly differentiated squamous cell carcinoma (PDSCC). Methods: The expression of CerbB2, epidermal growth factor receptor (EGFR) and proliferating cell nuclear antigen (PCNA) in VNCC and PDSCC was detected by in situ hybridization and immunohistochemistry (SP method) End-labeled (ISLE) method was used to detect the apoptosis of cancer cells, and its prognosis and clinical features were compared. Results: (1) ISEL and PCNA staining intensity index (SI) in VCC was significantly higher than that in PDSCC; (2) The expression of CerbB2, EGFRmRNA and CerbB2 in VCC was not significantly different from PDSCC; ③The 5-year survival rate of VCC was higher than that of PDSCC . CONCLUSION: Compared with PDSCC, VNCC is a kind of cancer with active growth and differentiation, lower degree of differentiation but better prognosis.