The purpose of this paper is to improve the aerodynamic performances of the last stage turbine and the exhaust hood of a 600 MW steam turbine under design and off design conditions. During operation, strong flow interactions between the turbine and the exhaust hood impose influences on the flow behavior in the hood and lead to the unsatisfactory aerodynamic performance of the turbine and exhaust hood. So the exhaust hood has the potential to be improved in terms of aerodynamic efficiency. Considering the flow interactions between the turbine and the exhaust hood, the profiles of the diffuser end-wall were optimized. The coupled model turbine and model exhaust hood calculations and experiments were carried out to validate the effects of the optimization. Model experiments show that the design modifications resulted in a substantial increase in the overall pressure recovery coefficient. The flow and aerodynamic performances of the full-scale last stage turbine and full-scale exhaust hood were simulated to explore the flow physics alterations to the modification of diffuser geometry. The wet steam was selected as the flow medium. The actual flow fields under different operation conditions were analyzed. The purpose of this paper is to improve the aerodynamic performances of the last stage turbine and the exhaust hood of a 600 MW steam turbine under design and off design conditions. During operation, strong flow interactions between the turbine and the exhaust hood impose influences on the flow behavior in the hood and lead to the unsatisfactory aerodynamic performance of the turbine and exhaust hood. of the exhaust to have improved to terms of aerodynamic efficiency. the diffuser end-wall were optimized. The coupled experiments turbine that model exhaust hood calculations and experiments were carried out to validate the effects of the optimization. Model experiments show that the design modifications resulted in a substantial increase in the overall pressure recovery coefficient. The flow and aerodynamic performances of the full-scale last stage turbine and full-scale exhaust hood were simulated to explore the flow physics alterations to the modification of diffuser geometry. The wet steam was selected as the flow medium. The actual flow fields under different operating conditions were analyzed.