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目的研究CXCR4在结直肠癌病例中的表达情况,探讨趋化因子受体CXCR4在结直肠恶性肿瘤中的表达及临床意义。方法收集2007—2008年上海交通大学医学院附属瑞金医院微创外科临床医学中心结直肠癌标本51例,应用免疫组织化学染色法并结合组织芯片检测正常结直肠黏膜组织、结直肠癌组织中CXCR4蛋白的表达情况并进行统计学分析。结果 CXCR4蛋白在结直肠癌组织中表达的阳性率为72.5%,明显高于其在结直肠正常黏膜组织中的表达(阳性率9.8%),差异具有统计学意义(P=0.000),伴发转移的结直肠癌组织与未发生转移组相比,其CXCR4表达显著增强,差异具有统计学意义(P=0.025)在不同Ducks分期组中,C期与D期组(n=28)CXCR4表达明显高于A期与B期组(n=23),差异有统计学意义(P=0.009)结论 CXCR4表达与结直肠癌转移间存在密切关系,可能为结直肠癌转移的潜在治疗靶点
Objective To investigate the expression of CXCR4 in colorectal cancer cases and to explore the expression of chemokine receptor CXCR4 in colorectal cancer and its clinical significance. Methods Totally 51 colorectal cancer specimens from 2007 to 2008 were collected from Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine. Immunohistochemical staining and tissue microarray were used to detect the expression of CXCR4 in normal colorectal mucosa and colorectal cancer Protein expression and statistical analysis. Results The positive rate of CXCR4 protein expression in colorectal cancer was 72.5%, which was significantly higher than that in normal colorectal mucosa (positive rate 9.8%), the difference was statistically significant (P = 0.000) The expression of CXCR4 in metastatic colorectal cancer tissues was significantly higher than that in non-metastatic colorectal cancer tissues (P = 0.025). In different Ducks stage groups, CXCR4 expression in stage C and D (n = 28) (P = 0.009) .Conclusion There is a close relationship between the expression of CXCR4 and the metastasis of colorectal cancer, which may be a potential therapeutic target for the metastasis of colorectal cancer