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To study IgG subclasses for the hepatitis B virus (HBV) core antigen (anti-HBc) in different populations,acomparison was made between 104 chronic carriers (60 male and 44 female) and 434 recovered individuals (247male and 192 female).Biochemistry analyses of AST (aspartate aminotransferase) and ALT (alanineaminotransferase) were also performed.Among the 104 chronic carriers,21 patients were found to be ALT andAST abnormal (>25IU/ml).After comparing these ALT and AST abnormal patients with other ALT and ASTnormal chronic carriers,no statistical difference was observed in the OD values of the anti-HBe (p>0.05).TheELISA results showed the anti-HBc IgG subclass pattern was IgG1>IgG3>IgG4 in chronic carriers and IgG3>IgG1>IgG4 in recovered individuals (p<0.05).This result suggests the IgG1/IgG3 ratio may be related with HBVstatus.However,in spite of the different anti-HBc IgG1/IgG3 patterns demonstrated in different populations,bothanti-HBc IgG1 and IgG3 concentrations were significantly higher in chronic carriers (p<0.05).Therefore,both theanti-HBc IgG1/IgG3 ratio and their amounts differed.They may play a significant role in chronic carriers andrecovered individuals.The anti-HBc IgG subclass profiles of chronic carriers were not changed regardless of liverinflammation,and were independent of sex and age.Cellular & Molecular Immunology.2005;2(5):393-398.
To study IgG subclasses for the hepatitis B virus (HBV) core antigen (anti-HBc) in different populations, acomparison was made between 104 chronic carriers (60 male and 44 female) and 434 recovered individuals (247male and 192 female). Biochemistry analyzes of AST (aspartate aminotransferase) and ALT (alanine aminotransferase) were also performed. Among the 104 chronic carriers, 21 patients were found to be ALT andAST abnormal (> 25IU / ml) .After comparing these ALT and AST abnormal patients with other ALT and ASTnormal The ELISA results showed the anti-HBc IgG subclass pattern was IgG1> IgG3> IgG4 in chronic carriers and IgG3> IgG1> IgG4 in recovered individuals (p <0.05) .This result suggests the the IgG1 / IgG3 ratio may be related with HBVstatus.However, in spite of the different anti-HBc IgG1 / IgG3patterns demonstrated in different populations, bothanti-HBc IgG1 and IgG3 concentrations were significantly hi Both in anti-HBc IgG subclass profiles of chronic carriers were not changed regardless of liver inflammation, and were independent of sex and age. Cellular & Molecular Immunology. 2005; 2 (5): 393-398.