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目的:进一步研究应激所致的心肌能量代谢变化及造成心肌损伤的机制.方法:将大鼠放置温水[(20±1)℃]浸泡应激.在应激0.5,1,2,4,6h后采用差速离心法分离线粒体,用氧电极法测定NADH氧化酶、琥珀酸氧化酶、细胞色素C氧化酶的活性及其变化和运用β受体阻滞剂对其的影响.结果:不同应激状态下氧化酶的活性与正常组比较相差显著,在应激开始阶段活性增高而后期逐渐下降.运用β受体阻滞剂后其变化趋势无变化,但使应激后氧化酶活性下降时间向后推移.结论:应激后线粒体呼吸功能变化有一定规律.应用β受体阻滞剂不能阻断其变化过程.
Objective: To further study the changes of myocardial energy metabolism induced by stress and the mechanism of myocardial injury. Methods: Rats were placed in warm water [(20 ± 1) ℃] soaking stress. Mitochondria were isolated by differential centrifugation at 0.5, 1, 2, 4 and 6 h after stress. The activities of NADH oxidase, succinate oxidase and cytochrome C oxidase and their changes were determined by oxygen electrode method. Receptor blockers on its impact. Results: The activity of oxidase under different stress state was significantly different from that of the normal group, and increased at the beginning of stress and decreased gradually at the later stage. The use of β-blocker change trend after its change, but the post-stress oxidative enzyme activity decline time backward. Conclusion: The change of mitochondrial respiratory function after stress has some rules. Application of β-blockers can not block the process of change.