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革兰阴性细菌的内毒素或脂多糖(LPS)是全身感染的重要致病因子,可通过一系列病理生理改变,导致成人呼吸窘迫综合征(ARDS)。后者的高病死率是由于组织损伤导致多器官衰竭所致。多形核白细胞(PMN)与组织损伤有关。在炎症介质的作用下,PMN聚集到炎症部位,发挥机体防御作用,但同时又会引起组织损伤。PMN含有强大抗菌作用的酶和肽类物质,在兔中已分离出6种中性粒细胞肽
Endotoxin or lipopolysaccharide (LPS) of Gram-negative bacteria is an important virulence factor of systemic infection and can cause adult respiratory distress syndrome (ARDS) through a series of pathophysiological changes. The latter high mortality is due to tissue damage caused by multiple organ failure. Polymorphonuclear leukocytes (PMN) are associated with tissue damage. In the role of the inflammatory mediators, PMN accumulates to the site of inflammation, play a body defensive role, but at the same time can cause tissue damage. PMN Contains potent antibacterial enzymes and peptides that have been isolated from six types of neutrophil peptides