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目的探讨血清白血病抑制因子(LIF)、肿瘤坏死因子-α(TNF-α)、雌二醇(E2),孕酮(P)、β-人绒毛膜促性腺激素(β-HCG)在异位妊娠早期诊断中的作用。方法选取2005年12月至2006年7月间在深圳石岩医院妇科住院的异位妊娠(EP)、先兆流产(TA)和正常宫内妊娠(NIUP)患者各32例,采用放射免疫法(RIA)检测血清中LIF、TNF-α、E2、P、β-HCG。结果EP组与TA组、NIUP组血清LIF[(2.37±2.13)ng/L对(8.83±6.96)ng/L,(8.29±6.70)ng/L],E2[(416.80±308.83)pmol/L对(2186.37±722.23)pmol/L,(2592.89±485.57)pmol/L]及β-HCG[(7726.60±2313.52)U/L对(24077.90±7536.69)U/L,(35444.50±34634.88)U/L]比较差异有统计学意义(P<0.05)。P在EP与TA组、NIUP各组间差异均有统计学意义[分别为(12.90±6.12)nmol/L,(45.90±12.39)nmol/L,(87.11±12.24)nmol/L,P<0.05)]。结论单次检测血清β-HCG对早期异位妊娠鉴别诊断意义可能不大;TNF-α尚不能作为早期异位妊娠诊断指标;检测LIF、E2、P对早期异位妊娠诊断可能有一定的临床价值;联合单次检测血清LIF、E2、P、β-HCG可能为临床早期诊断异位妊娠提供一个指标。
Objective To investigate the expression of leukemia inhibitory factor (LIF), tumor necrosis factor-α (TNF-α), estradiol (E2), progesterone (P) and β-human chorionic gonadotropin (β-HCG) The role of early pregnancy diagnosis. Methods Thirty-two patients with ectopic pregnancy (EP), threatened abortion (TA) and normal intrauterine pregnancy (NIUP) were enrolled in gynecology department of Shenzhen Shiyan Hospital from December 2005 to July 2006. Radioimmunoassay RIA) to detect serum LIF, TNF-α, E2, P, β-HCG. Results Compared with TA group and NIUP group, the serum levels of LIF (8.83 ± 6.96 ng / L vs 8.29 ± 6.70 ng / L, E2 [(416.80 ± 308.83) pmol / L (2186.37 ± 722.23) pmol / L, (2592.89 ± 485.57) pmol / L] and β-HCG [(7726.60 ± 2313.52) U / L vs (24077.90 ± 7536.69) U / L and (35444.50 ± 34634.88] U / L ] Difference was statistically significant (P <0.05). There were significant differences in P between EP group and TA group [(12.90 ± 6.12) nmol / L, (45.90 ± 12.39) nmol / L and (87.11 ± 12.24) nmol / L respectively) )]. Conclusion Single serum β-HCG in early ectopic pregnancy diagnosis may not be meaningful; TNF-α still can not be used as an early diagnosis of ectopic pregnancy index; detection of LIF, E2, P early diagnosis of ectopic pregnancy may have some clinical Value. Combined detection of serum LIF, E2, P and β-HCG may provide an index for early diagnosis of ectopic pregnancy.