邻—羟基苯乙酮是有机及药物合成的重要原料或中间体。对其合成方法曾有不少学者从Tries重排反应的研究中作过报道,但收率都是对-轻基苯乙酮较高而邻位异构体较低,仅29～37％。文献方法大体分为两种:一种是采用溶剂如二硫化碳、苯和硝基苯等溶解样品,在较低温度下回流或反应,分离出溶剂后再以油浴升温反应。然后经酸水分解、溶剂提取、分级蒸馏等,操作繁琐,收率低;另一种方法是不用溶剂,由乙酸苯酯与无水三氯化铝催 O-hydroxyacetophenone is an important raw material or intermediate for organic and drug synthesis. Many scholars have reported the Tries rearrangement reaction, but the yields are higher for p-hydroxyacetophenone and lower for the ortho-isomer, only 29-37%. Literature methods are broadly divided into two types: one is to dissolve the sample with solvents such as carbon disulfide, benzene and nitrobenzene, reflux or reaction at lower temperature, the solvent is separated and then the reaction was heated in an oil bath. Then acid-water decomposition, solvent extraction, fractionation distillation, tedious operation, low yield; the other is without solvent, the reaction of phenyl acetate and anhydrous aluminum chloride