本文报告甲基胆蒽及促癌物黄芫花和乌桕与甲基胆蒽协同诱发的小鼠实验性宫颈癌LDH及其同工酶谱的变化。患宫颈癌小鼠血清及癌组织LDH活力均增高,LDH_5增多,LDH_3、LDH_2和LDH_1减少或缺失。即M亚基增多,H亚基减少。这些改变以协同用乌桕组最明显,协同用黄芜花组次之。表明患宫颈癌小鼠基因表达的调控发生了改变。 This paper reports the changes of LDH and its isoenzyme spectrum in mouse experimental cervical cancer induced by the cooperation of methylcholanthrene and the promoters of jacaranda flowers and black peony and methylcholanthrene. The activity of LDH in serum and cancer tissues of mice with cervical cancer were all increased, LDH_5 was increased, and LDH_3, LDH_2, and LDH_1 were reduced or absent. That is, the number of M subunits increases and the H subunit decreases. These changes were most obvious in the synergistic use of the T. sinensis group, followed by the synergistic use of the scutellaria group. It shows that the regulation of gene expression in cervical cancer mice has changed.