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目的观察周剂量多西他赛联合顺铂治疗老年晚期非小细胞肺癌的近期疗效和毒副反应。方法86例经病理证实的晚期非小细胞肺癌患者,多西他赛35 mg/m2第1、8天给药,联合顺铂25 mg/m2,第1~4天给药,21 d为1个周期。结果86例患者完成2个周期化疗后评价近期疗效,完全缓解3例,部分缓解38例,稳定40例,进展5例,总有效率47.67%。主要毒副反应为骨髓抑制、脱发、消化道反应,但均较轻微。结论周剂量多西他赛联合顺铂方案治疗老年非小细胞肺癌疗效明显,毒副反应轻,耐受性好。
Objective To observe the short-term effects and side effects of weekly doses of docetaxel plus cisplatin in the treatment of elderly patients with advanced non-small cell lung cancer. METHODS: Eighty-six patients with pathologically confirmed advanced non-small cell lung cancer were treated with docetaxel 35 mg / m2 on days 1 and 8 with cisplatin 25 mg / m2 on days 1 to 4 and 1 d on day 1 A cycle. Results 86 patients completed two cycles of chemotherapy after the evaluation of short-term efficacy, complete remission in 3 cases, partial remission in 38 cases, stable in 40 cases, progress in 5 cases, the total effective rate was 47.67%. The main side effects of bone marrow suppression, hair loss, gastrointestinal reactions, but are minor. Conclusion Week dose of docetaxel combined with cisplatin in the treatment of elderly non-small cell lung cancer has obvious curative effect, light toxicity and good tolerance.