论文部分内容阅读
目的：研究人胎视网膜内纤维连接蛋白（ｆｉｂｒｏｎｅｃｔｉｎ，Ｆｎ）、碱性纤维母细胞生长因子（ｂａ－ｓｉｃ－ｆｉｂｒｏｂｌａｓｔｇｒｏｗｔｈｆａｃｔｏｒ，ｂ－ＦＧＦ）和星形胶质细胞对血管两种发生方式的调节作用。方法：收集１３～４０周胎儿视网膜８６例，免疫组织化学染色，光镜观察。结果：梭形细胞、血管内皮细胞均呈Ｆｎ免疫阳性反应，梭形细胞前方的基质中有Ｆｎ免疫反应物沉积，血管内皮细胞、节细胞和视锥细胞呈ｂ－ＦＧＦ阳性反应，后两种细胞的出现先于邻近区域血管的形成；星形胶质细胞紧密伴随梭形细胞向锯齿缘迁移，其突起包裹两种方式发生的血管。结论：Ｆｎ、ｂ－ＦＧＦ和星形胶质细胞这三种因素对血管发生的两种方式均有促进作用。
OBJECTIVE: To study the regulatory effect of fibronectin (Fn), b-FGF and astrocyte on the occurrence of vascular in human retina. Methods: Totally 86 fetus fetuses from 13 to 40 weeks were collected for immunohistochemical staining and light microscopy. Results: Fn immunoreactive cells were present in both spindle cells and vascular endothelial cells. Fn immunoreactive material was deposited in the matrix in front of the spindle cells. The endothelial cells, ganglion cells and cones showed b-FGF positive reaction. The latter two The appearance of cells precedes the formation of blood vessels in adjacent areas; astrocytes migrate closely to the serrated edges of the spindle cells, and their projections envelop blood vessels in two ways. Conclusion: The three factors of Fn, b-FGF and astrocyte can promote angiogenesis in both ways.