动物试验及临床研究表明,机体在各种应激状态下,下丘脑、垂体、脊髓、交感神经节及肾上腺髓质大量释放内源性阿片样物质(OLS)β-内啡肽(β-EP)、脑啡肽、强啡肽。OLS通过与脑干等部位的阿片受体结合,引起一系列病理效应。基于此理论基础,纳洛酮(NAL)作为阿片受体阻滞剂,广泛应 Animal experiments and clinical studies have shown that the body in a variety of stress conditions, the hypothalamus, pituitary, spinal cord, sympathetic ganglia and adrenal medulla mass release of endogenous opioid (OLS) β-endorphin (β-EP ), Enkephalin, dynorphin. OLS causes a series of pathological effects by binding opioid receptors such as brain stem. Based on this theoretical basis, naloxone (NAL) is widely used as an opiate receptor blocker