目的探讨p15、p16基因在肺癌组织中纯合缺失情况。方法对59例肺癌组织和14例肺部良性组织，应用PCR法检测p15、p16基因纯合缺失情况。结果在肺癌组织中p15、p16基因改变频率分别为11．9％、23．8％。而在肺部良性组织中只有p16基因1例阳性。结论p16基因在肺癌组织中改变率相对较高；p15、p16基因在肺癌的研究中可能具有一定的价值。 Objective To investigate the loss of homozygosity of p15 and p16 genes in lung cancer. Methods 59 cases of lung cancer tissues and 14 cases of benign lung tissues were collected. The homozygous deletion of p15 and p16 genes was detected by PCR. Results The frequencies of p15 and p16 gene mutations in lung cancer tissues were 11.9% and 23.8%, respectively. Only one positive case of p16 gene was found in benign lung tissues. Conclusion The rate of p16 gene mutation in lung cancer is relatively high. The p15 and p16 genes may have some value in the study of lung cancer.