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本文应用正交设计、随机区组和平衡不完全区组实验设计,采用胆酸钠、依地酸二钠(EDTA·2 Na)和肝素,对13例(127枚)胆固醇结石、4例(28枚)表面钙化胆固醇结石、17例(62枚)胆色素结石和1例(8枚)碳酸钙结石作了体外溶石实验。结果表明各类胆石的溶石配方应有所不同:胆固醇结石和表面钙化胆固醇结石为200mM胆酸钠-2％EDTA·2 Na;胆色素结石为100mM胆酸钠-2％EDTA·2Na;而碳酸钙结石为2％EDTA·2Na。肝素对上述四种胆石均无明显体外溶石作用,亦不能增强胆酸钠或胆酸钠-EDTA·2 Na等的溶石作用。
Orthogonal design, randomized block design and incomplete block design were used in this study. Cholesterol calculi of 13 cases (127 pieces) and four cases of cholesterol stones (EDTA) were obtained by sodium cholate, EDTA · 2 Na and heparin 28 calcified surface calcified calculi, 17 cases (62 pieces) and 1 case (8 pieces) of calcium carbonate stones. The results show that all types of gallstone stone dissolve the formula should be different: the cholesterol calculi and calcified surface calculi of calcium carbonate is 200mM sodium 2% EDTA 2 Na; bile pigment stones 100mM sodium cholate - 2% EDTA 2Na; and Calcium carbonate stones are 2% EDTA · 2Na. Heparin on the above four kinds of gallstone no obvious in vitro dissolution of stone, can not enhance the sodium cholate or sodium cholate - EDTA 2 Na et al.