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目的:对我院上报的加替沙星不良反应/事件报告进行调查分析,为临床提供合理用药参考。方法:收集我院2007～2011年上报的54例加替沙星不良反应/事件报告资料,进行统计分析及临床应用评价。结果:54例患者中,男6例,女48例。加替沙星不良反应以皮肤及其附件损害、神经系统损害和胃肠系统损害为主,分别占17.65%、17.65%、13.73%。出现静脉炎的比例较高,占12.75%。85.19%用于泌尿生殖系统抗感染治疗;46.30%为抗感染治疗的用药指征不合理。结论:加替沙星在临床广泛用于泌尿生殖系感染的经验治疗。临床应用时存在抗感染治疗的用药指征不合理、输注速度过快等不合理现象。临床医生应严格掌握加替沙星用药指征,以减少不良反应的发生,减缓细菌耐药性的增长。
OBJECTIVE: To investigate and report on the adverse reactions and events reported by Gatifloxacin in our hospital to provide a reasonable reference for clinical use. Methods: 54 cases of gatifloxacin adverse reactions / events reported in our hospital from 2007 to 2011 were collected for statistical analysis and clinical application evaluation. Results: 54 patients, 6 males and 48 females. The adverse effects of gatifloxacin were mainly skin and its accessory damage, nervous system damage and gastrointestinal system damage, accounting for 17.65%, 17.65% and 13.73% respectively. A higher incidence of phlebitis, accounting for 12.75%. 85.19% for anti-infective treatment of genitourinary system; 46.30% for anti-infective treatment medication indications unreasonable. Conclusion: Gatifloxacin is widely used clinically for the treatment of genitourinary infections. There are irrational indications for anti-infective therapy in clinical application and irrational infusion rate. Clinicians should strictly control gatifloxacin drug indications to reduce the incidence of adverse reactions and slow the growth of bacterial resistance.