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肾间质纤维化可导致肾功能损害 ,其发病机理主要与细胞外基质 (ECM )过度沉积及细胞因子、生长因子作用有关 ;其治疗方法主要是抑制纤维细胞活性及ECM合成 ,刺激ECM降解。
Renal interstitial fibrosis can lead to renal dysfunction. Its pathogenesis is mainly related to the excessive deposition of extracellular matrix (ECM) and the effects of cytokines and growth factors. The treatment is mainly to inhibit fibroblast activity and ECM synthesis and stimulate ECM degradation.