患女,42岁,已婚,因两腋下、下腹部及会阴区皮肤僵硬色素沉着1月入院。患者于入院前1月自感两上肢活动不便,继而发现两腋下、胸前、下腹部及会阴区皮肤僵硬、感觉异常,并有色素沉着及皮肤表面有小米粒样隆起,有时感上腹饱胀不适且逐渐加重。检查见两腋下、乳房、下腹、会阴等处皮肤增厚,皮嵴凸起,皮沟加深,皮肤干燥、粗糙,表面呈淡褐色,境界尚清楚,有散在或平行的小米粒至黄豆大小柔软结节及乳头样增殖,病理报告为黑棘皮病,以维生素A、类固醇激素等治疗。入院后半月因上消化道出血作胃镜检查,明确诊断为胃体癌。手术见 The woman, 42 years old, was married and was admitted to hospital in January due to stiffness and pigmentation of the skin under both hernias, lower abdomen and perineum area. The patient felt inconvenience in the activities of the two upper limbs before entering the hospital in January, and then found that the skin in both underarms, chest, lower abdomen, and perineum area was stiff and sensory abnormalities, and there was hyperpigmentation and grain-like bumps on the surface of the skin. Fullness and discomfort increase gradually. Check the skin of the two underarms, breasts, lower abdomen, perineum, etc., thicken the skin, raise the skin, deepen the skin groove, the skin is dry, rough, the surface is pale brown, the realm is still clear, there are scattered or parallel small grains to the size of soybeans Soft nodules and papillary hyperplasia, pathological reports of black acanthosis, treatment with vitamin A, steroid hormones. Half a month after admission, gastroscopic examination of upper gastrointestinal bleeding confirmed the diagnosis of gastric cancer. See you